5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid

Base Information

Chemical Name:5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid
CAS No.:17385-94-3
Molecular Formula:C₁₈H₂₂N₂O₃S₂
Molecular Weight:378.516
Hs Code.:
DSSTox Substance ID:DTXSID801133890

Synonyms:DTXSID801133890;AKOS034345846;5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid;17385-94-3

Suppliers and Price of 5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:378.10718492
Heavy Atom Count:25
Complexity:538

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN(CC)C1=CC=C(C=C1)C=C2C(=O)N(C(=S)S2)CCCC(=O)O

Technology Process of 5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid

There total 4 articles about 5-[[4-(Diethylamino)phenyl]methylene]-4-oxo-2-thioxo-3-thiazolidinebutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18623-60-4
3-(3‘-hydroxycarbonylpropyl)-2-thioxothiazolidin-4-one

: 120-21-8
4-Diethylaminobenzaldehyde

: 17385-94-3
5-(4′-N,N-diethylaminobenzylidene)rhodanine-3-butyric acid

Guidance literature:: 3-(3‘-hydroxycarbonylpropyl)-2-thioxothiazolidin-4-one; 4-Diethylaminobenzaldehyde; With triethylamine; In isopropyl alcohol; for 5h; Molecular sieve; Reflux; Inert atmosphere;

With hydrogenchloride; In water;
DOI:10.1007/s00044-017-1852-7

Reference yield:

: ADTC

: 17385-94-3
5-(4′-N,N-diethylaminobenzylidene)rhodanine-3-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: water / 7 h / 15 °C

2: hydrogenchloride / water / 0.33 h / 90 °C

3: triethylamine / isopropyl alcohol / 5 h / Molecular sieve; Reflux; Inert atmosphere

With hydrogenchloride; triethylamine; In water; isopropyl alcohol;
DOI:10.1007/s00044-017-1852-7

Reference yield:

C₇H₁₀NO₄S₂^(1-)*K⁽¹⁺⁾: C₇H₁₀NO₄S₂^(1-)*K⁽¹⁺⁾

: 17385-94-3
5-(4′-N,N-diethylaminobenzylidene)rhodanine-3-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 0.33 h / 90 °C

2: triethylamine / isopropyl alcohol / 5 h / Molecular sieve; Reflux; Inert atmosphere

With hydrogenchloride; triethylamine; In water; isopropyl alcohol;
DOI:10.1007/s00044-017-1852-7