Chemical Property of Ingenol
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Melting Point:153 °C
- Refractive Index:1.625
- Boiling Point:523.785 °C at 760 mmHg
- PKA:12.06±0.70(Predicted)
- Flash Point:284.654 °C
- PSA：97.99000
- Density:1.33 g/cm3
- LogP:0.81520
- Storage Temp.:−20°C
- Solubility.:DMSO: soluble
- XLogP3:0.2
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:1
- Exact Mass:348.19367399
- Heavy Atom Count:25
- Complexity:707
- Purity/Quality:
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95%-98% *data from raw suppliers
Ingenol 98% *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xi
- Hazard Codes:Xi
- Statements:
38-41
- Safety Statements:
26-36
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1CC2C(C2(C)C)C3C=C(C(C4(C1(C3=O)C=C(C4O)C)O)O)CO
- Isomeric SMILES:C[C@@H]1C[C@@H]2[C@@H](C2(C)C)[C@@H]3C=C([C@H]([C@]4([C@@]1(C3=O)C=C([C@@H]4O)C)O)O)CO
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Description
Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus.1 It is a protein kinase C activator that displays a Ki value of 30 μM and an ED50 value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis. Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a Ki value of 30 μM and an ED50 value of 27 μM in vitro. Most ingenol esters are tumor-promoting. However, ingenol mebutate possesses anti-tumor activity when used topically for actinic keratosis.
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Uses
Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.
