(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate

Base Information

• Chemical Name: (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate
• CAS No.: 1428424-06-9
• Molecular Formula: C₃₁H₄₆O₄
• Molecular Weight: 482.704
• Mol file: 1428424-06-9.mol

Synonyms:(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate

Chemical Property of (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate

There total 5 articles about (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexanol (1428424-05-8) + cyclohexen-3-one-1-carboxylic acid (24079-79-6) → (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate (1428424-06-9)

Guidance literature:

With dmap; diisopropyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; for 12h;

DOI:10.3390/molecules18021626

Reference yield:

C26H42O3 → (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate (1428424-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol / 8 h / 85 °C / Inert atmosphere

2: diisopropyl-carbodiimide; dmap / dichloromethane / 12 h / 0 - 20 °C

With dmap; water; sodium hydroxide; diisopropyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.3390/molecules18021626

Reference yield:

(-)-8-[(p-methoxy)phenyl]menthol (80868-36-6) → (1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 3-oxocyclohex-1-enecarboxylate (1428424-06-9)

Guidance literature:

Multi-step reaction with 5 steps

1: iodine / 20 °C

2: boron tribromide / dichloromethane / -78 - -25 °C

3: caesium carbonate / N,N-dimethyl-formamide / 12 h / 65 °C / Inert atmosphere

4: sodium hydroxide; water / ethanol / 8 h / 85 °C / Inert atmosphere

5: diisopropyl-carbodiimide; dmap / dichloromethane / 12 h / 0 - 20 °C

With dmap; water; iodine; boron tribromide; caesium carbonate; sodium hydroxide; diisopropyl-carbodiimide; In ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.3390/molecules18021626

upstream raw materials:

(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexanol

cyclohexen-3-one-1-carboxylic acid

(-)-8-[(p-methoxy)phenyl]menthyl acetate

(-)-8-[(p-methoxy)phenyl]menthol

Downstream raw materials:

(1S,6S)-(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 5-oxobicyclo[4.2.0]octane-1-carboxylate

(1R,6R)-(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 5-oxobicyclo[4.2.0]octane-1-carboxylate

(3aR,3bS,7aS,7bS)-(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 7-oxodecahydro-1H-cyclopenta[3,4]cyclobuta[1,2]benzene-3b-carboxylate

(3aS,3bS,7aS,7bR)-(1R,2S,5R)-5-methyl-2-(2-(4-(octyloxy)phenyl)propan-2-yl)cyclohexyl 7-oxodecahydro-1H-cyclopenta[3,4]cyclobuta[1,2]benzene-3b-carboxylate