4-benzylamino-6,7-difluoroquinazoline

Base Information

• Chemical Name: 4-benzylamino-6,7-difluoroquinazoline
• CAS No.: 625080-61-7
• Molecular Formula: C₁₅H₁₁F₂N₃
• Molecular Weight: 271.269
• Mol file: 625080-61-7.mol

Synonyms:4-benzylamino-6,7-difluoroquinazoline

Chemical Property of 4-benzylamino-6,7-difluoroquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzylamino-6,7-difluoroquinazoline

There total 3 articles about 4-benzylamino-6,7-difluoroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzylamine (100-46-9) + 4-chloro-6,7-difluoroquinazoline (625080-60-6) → 4-benzylamino-6,7-difluoroquinazoline (625080-61-7)

Guidance literature:

With triethylamine; In isopropyl alcohol; at 20 ℃; for 8h;

DOI:10.1016/S0968-0896(02)00338-3

Reference yield:

6,7-difluoro-3,4-dihydroquinazolin-4-one (205259-37-6) → 4-benzylamino-6,7-difluoroquinazoline (625080-61-7)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / dimethylformamide / 2 h / Heating

2: 188 mg / Et₃N / propan-2-ol / 8 h / 20 °C

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/S0968-0896(02)00338-3

Reference yield:

2-amino-4,5-difluorobenzamide (211374-80-0) → 4-benzylamino-6,7-difluoroquinazoline (625080-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 89 percent / HCl / 4 h / 20 °C

2: SOCl₂ / dimethylformamide / 2 h / Heating

3: 188 mg / Et₃N / propan-2-ol / 8 h / 20 °C

With hydrogenchloride; thionyl chloride; triethylamine; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/S0968-0896(02)00338-3

upstream raw materials:

benzylamine

4-chloro-6,7-difluoroquinazoline

6,7-difluoro-3,4-dihydroquinazolin-4-one

2-amino-4,5-difluorobenzamide