(R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

Base Information

Chemical Name:(R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid
CAS No.:1268474-82-3
Molecular Formula:C₁₄H₁₈ClNO₅
Molecular Weight:315.754
Hs Code.:

Synonyms:(R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

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Chemical Property of (R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

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Technology Process of (R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

There total 2 articles about (R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1268474-80-1
(R)-methyl 2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoate

: 1268474-82-3
(R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

Guidance literature:: With water; In tetrahydrofuran; water; at 20 ℃; for 0.416667h;

Reference yield:

: 170701-87-8
L-1-Benzyloxycarbonylaziridine-2-carboxylic acid methyl ester

: 1268474-82-3
(R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0.25 h / 20 °C

2: water / water; tetrahydrofuran / 0.42 h / 20 °C

With boron trifluoride diethyl etherate; water; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1268474-82-3
(R)-2-(benzyloxycarbonylamino)-3-(1-chloropropan-2-yloxy)propanoic acid

: 1-(4-(5-(cyclopropylmethyl)-6a,9-dimethyl-6-oxo-5,6,6a,7,9,10-hexahydro-[1,4]oxazino[3,4-h]pteridin-2-yl)phenyl)-3-methylurea

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 2.5 h / 760.05 Torr

2: triethylamine / methanol / 36.5 h / 80 - 100 °C / Reflux; Condensed phase; Sealed

3: sodium hydride / N,N-dimethyl-formamide; mineral oil / 34 h / 0 - 90 °C

4: sodium t-butanolate / dimethyl sulfoxide / 14 h / -78 - 20 °C

5: sodium hydrogencarbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / methanol / 4.75 h / 100 °C / Microwave Irradiation

With hydrogen; sodium hydride; sodium hydrogencarbonate; triethylamine; sodium t-butanolate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;