N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

Base Information

Chemical Name:N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide
CAS No.:1422018-78-7
Molecular Formula:C₂₂H₂₂N₄OS
Molecular Weight:390.509
Hs Code.:

Synonyms:N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

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Chemical Property of N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

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Technology Process of N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

There total 8 articles about N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1422022-19-2
3-(1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzonitrile

: 1422018-78-7
N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

Guidance literature:: With hydroxylamine; In water; dimethyl sulfoxide; at 140 ℃; for 0.25h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 1422022-18-1
tert-butyl 5-(3-cyano-2-(3-methylthiophen-2-yl)-5-propylphenyl)-1H-indazole-1-carboxylate

: 1422018-78-7
N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: hydroxylamine / water; dimethyl sulfoxide / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

With hydroxylamine; trifluoroacetic acid; In dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 1422022-14-7
3-bromo-2-(3-methylthiophen-2-yl)-5-propylbenzonitrile

: 1422018-78-7
N'-hydroxy-3-( 1H-indazol-5-yl)-2-(3-methylthiophen-2-yl)-5-propylbenzimidamide

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; ethanol; 1,2-dimethoxyethane / 0.33 h / 140 °C / Inert atmosphere; Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3: hydroxylamine / water; dimethyl sulfoxide / 0.25 h / 140 °C / Inert atmosphere; Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; hydroxylamine; potassium carbonate; trifluoroacetic acid; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; dimethyl sulfoxide; 1: |Suzuki Coupling;