N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

Base Information

Chemical Name:N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide
CAS No.:1402593-35-4
Molecular Formula:C₂₂H₂₃F₃N₄OS
Molecular Weight:448.512
Hs Code.:

Synonyms:N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

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Chemical Property of N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

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Technology Process of N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

There total 7 articles about N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1402595-17-8
4-{6-bromo-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}-N-cyclopropyl-2-methylbenzamide

: 5188-07-8
sodium thiomethoxide

: 1402593-35-4
N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

Guidance literature:: In dimethyl sulfoxide; at 70 - 100 ℃; for 4h;

Reference yield:

: 38875-53-5
5-bromo-pyridine-2,3-diamine

: 1402593-35-4
N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: isopropyl alcohol / 20 °C / Reflux; Inert atmosphere

2.1: N-iodo-succinimide / tetrahydrofuran / 0 °C

3.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 20 - 80 °C

4.1: 1,1-dichloroethane / 2 h / 20 °C

4.2: 1 h

5.1: dimethyl sulfoxide / 4 h / 70 - 100 °C

With N-iodo-succinimide; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,1-dichloroethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 345965-99-3
4-bromo-N-cyclopropyl-2-methylbenzamide

: 1402593-35-4
N-cyclopropyl-2-methyl-4-{6-(methylsulfanyl)-8-[(3,3,3-trifluoropropyl)amino]imidazo[1,2-a]pyridin-3-yl}benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium acetate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 6 h / Reflux

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; tetrahydrofuran / 20 - 80 °C

3.1: 1,1-dichloroethane / 2 h / 20 °C

3.2: 1 h

4.1: dimethyl sulfoxide / 4 h / 70 - 100 °C

With potassium acetate; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; 1,1-dichloroethane; water; dimethyl sulfoxide;