(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Chemical Name:(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester
CAS No.:202214-56-0
Molecular Formula:C₄₂H₆₃N₅O₈
Molecular Weight:765.991
Hs Code.:

(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Synonyms:(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Chemical Property of (S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

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Technology Process of (S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

There total 6 articles about (S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 202214-55-9
(S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-3-{[(S)-2-tert-butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-methoxycarbonylmethyl-amino}-propionylamino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

: 202214-56-0
(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 23 ℃; for 14h; under 760 Torr;
DOI:10.1016/S0040-4039(97)10530-5

Reference yield:

: 47375-34-8
Boc-Tyr(t-Bu)-OH

: 202214-56-0
(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / DIEA, BOP / CH₂Cl₂ / 0 degC then 23 degC, overnight

2: LiAlH₄ / diethyl ether / 0.75 h / 0 °C

3: NaCNBH₃, AcOH / methanol / 24 h / 23 °C

4: 2.) EDS, NHS / 1.) CH₃CN, 65 degC; 2.) DMF, 23 degC, 24 h

5: 92 percent / H₂ / 10percent Pd/C / ethanol / 14 h / 23 °C / 760 Torr

With 1-hydroxy-pyrrolidine-2,5-dione; lithium aluminium tetrahydride; hydrogen; sodium cyanoborohydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; diethyl ether; ethanol; dichloromethane;
DOI:10.1016/S0040-4039(97)10530-5

Reference yield:

: 28635-78-1
L-phenylalanyl-L-leucine tert-butyl ester

: 202214-56-0
(S)-2-[(S)-2-({(S)-4-[(S)-2-tert-Butoxycarbonylamino-3-(4-tert-butoxy-phenyl)-propyl]-6-oxo-piperazine-2-carbonyl}-amino)-3-phenyl-propionylamino]-4-methyl-pentanoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) EDS, NHS / 1.) CH₃CN, 65 degC; 2.) DMF, 23 degC, 24 h

2: 92 percent / H₂ / 10percent Pd/C / ethanol / 14 h / 23 °C / 760 Torr

With 1-hydroxy-pyrrolidine-2,5-dione; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1016/S0040-4039(97)10530-5