3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene

Base Information

• Chemical Name: 3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene
• CAS No.: 476351-89-0
• Molecular Formula: C₂₂H₃₀O₇S
• Molecular Weight: 438.542
• Mol file: 476351-89-0.mol

Synonyms:3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene

Chemical Property of 3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene

There total 1 articles about 3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Ethyl 4-hydroxybenzoate (120-47-8) + 2-(((2-iodoethyl)triethoxy)oxy)-4-methylthiophene → 3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene (476351-89-0)

Guidance literature:

With potassium carbonate; potassium iodide; In acetone; for 60h; Heating;

DOI:10.1021/ja027387l

Reference yield: 93.0%

3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene (476351-89-0) → 3-((4-(p-carboxyphenyl)tetraethoxy)oxy)-4-methylthiophene (476351-90-3)

Guidance literature:

With sodium hydroxide; In ethanol; for 16h; Heating;

DOI:10.1021/ja027387l

Reference yield:

3-[(ethyl-4-phenylcarboxylate)-1-(tetraethoxy)oxy]-4-methylthiophene (476351-89-0) → 3-(N-succinimido-p-phenylcarboxylate(tetraethoxy)oxy)-4-methylthiophene (476351-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 93 percent / aq. NaOH / ethanol / 16 h / Heating

2: 85 percent / DCC; DMAP / CH₂Cl₂ / 35 h

With dmap; sodium hydroxide; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/ja027387l

upstream raw materials:

Ethyl 4-hydroxybenzoate

Downstream raw materials:

3-((4-(p-carboxyphenyl)tetraethoxy)oxy)-4-methylthiophene

3-(N-succinimido-p-phenylcarboxylate(tetraethoxy)oxy)-4-methylthiophene