17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

Base Information

Chemical Name:17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol
CAS No.:150711-22-1
Molecular Formula:C₃₃H₃₂O₂Si
Molecular Weight:488.701
Hs Code.:

Synonyms:17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

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Chemical Property of 17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

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Technology Process of 17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

There total 5 articles about 17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 145628-96-2
3-(Benzoyloxy)-17-<(tert-butyldiphenylsilyl)oxy>-15,16-dihydrocyclopenta phenanthrene

: 150711-22-1
17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; for 1h; Ambient temperature;
DOI:10.1021/jo00054a018

Reference yield:

: 792-07-4
3-methoxy-16,17-dihydro-15H-cyclopenta -phenanthren-17-one

: 150711-22-1
17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

Guidance literature:: Multi-step reaction with 5 steps

1: BBr₃ / CH₂Cl₂ / 1.5 h / -78 °C

2: 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 3 h

3: 83 percent / NaBH₄ / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

4: 81 percent / 4-(N,N-dimethylamino)pyridine, imidazole / CH₂Cl₂ / 2 h / Ambient temperature

5: 100 percent / 0.1 M KOH / tetrahydrofuran; methanol / 1 h / Ambient temperature

With 1H-imidazole; dmap; potassium hydroxide; sodium tetrahydroborate; boron tribromide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00054a018

Reference yield:

: 24684-50-2
15,16-dihydro-3-hydroxycyclopenta phenanthren-17-one

: 150711-22-1
17-(tert-Butyl-diphenyl-silanyloxy)-16,17-dihydro-15H-cyclopenta[a]phenanthren-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 4-(N,N-dimethylamino)pyridine / CH₂Cl₂ / 3 h

2: 83 percent / NaBH₄ / tetrahydrofuran; methanol / 2.5 h / Ambient temperature

3: 81 percent / 4-(N,N-dimethylamino)pyridine, imidazole / CH₂Cl₂ / 2 h / Ambient temperature

4: 100 percent / 0.1 M KOH / tetrahydrofuran; methanol / 1 h / Ambient temperature

With 1H-imidazole; dmap; potassium hydroxide; sodium tetrahydroborate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00054a018