(2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

Base Information

Chemical Name:(2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine
CAS No.:181528-82-5
Molecular Formula:C₁₈H₂₀BrNO₄
Molecular Weight:394.265
Hs Code.:

Synonyms:(2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

Chemical Property:

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Technology Process of (2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

There total 9 articles about (2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 181528-81-4
4-Bromo-benzoic acid (2R,3S,6S)-6-furan-3-yl-3-methyl-4-oxo-piperidin-2-ylmethyl ester

: 181528-82-5
(2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

Guidance literature:: With potassium tri-sec-butyl-borohydride; In tetrahydrofuran; at -80 ℃; for 6h;

Reference yield:

: 121693-79-6,117431-83-1
(E)-tert-butyldimethyl-((3-methylpent-2-en-4-yn-1-yl)oxy)silane

: 181528-82-5
(2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

Guidance literature:: Multi-step reaction with 5 steps

1: 45 percent / Hg(OAc)2 / diethyl ether / Ambient temperature

2: 1.) ZnCl₂, 3.) aq. NaHCO₃

3: 88 percent / 3N aq. HCl / acetonitrile / 2 h

4: 100 percent / DMAP, pyridine / 0.17 h / Ambient temperature

5: 29 percent / K-selectride / tetrahydrofuran / 6 h / -80 °C

With pyridine; hydrogenchloride; dmap; mercury(II) diacetate; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; zinc(II) chloride; In tetrahydrofuran; diethyl ether; acetonitrile;

Reference yield:

: 181528-69-8
(S)-1-[(E)-4-(tert-Butyl-dimethyl-silanyloxy)-2-methyl-1-methylene-but-2-enyl]-2-methoxymethyl-pyrrolidine

: 181528-82-5
(2R,3S,4R,6S)-2-(p-bromobenzoyloxymethyl)-6-(3-furyl)-4-hydroxy-3-methylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) ZnCl₂, 3.) aq. NaHCO₃

2: 88 percent / 3N aq. HCl / acetonitrile / 2 h

3: 100 percent / DMAP, pyridine / 0.17 h / Ambient temperature

4: 29 percent / K-selectride / tetrahydrofuran / 6 h / -80 °C

With pyridine; hydrogenchloride; dmap; sodium hydrogencarbonate; potassium tri-sec-butyl-borohydride; zinc(II) chloride; In tetrahydrofuran; acetonitrile;