(S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol

Base Information

• Chemical Name: (S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol
• CAS No.: 927826-30-0
• Molecular Formula: C₁₄H₁₉NO₅
• Molecular Weight: 281.309
• Mol file: 927826-30-0.mol

Synonyms:(S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol

Chemical Property of (S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of (S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol

There total 1 articles about (S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol (927826-30-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 27 percent / NaHCO₃ / diethyl ether; H₂O / 20 h / 20 °C

2: chiral diphenylethanediamine-based Zn complex / diethyl ether / 20 h / 20 °C

With sodium hydrogencarbonate; chiral diphenylethanediamine-based Zn; In diethyl ether; water;

DOI:10.1021/ol063063g

Reference yield:

(S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol (927826-30-0) → acetic acid 2-benzyloxycarbonylamino-2-methyl-3-oxo-propyl ester

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃;

DOI:10.1021/ol063063g

Reference yield:

(S)-2-(benzyloxycarbonyl)amino-2-methyl-3-(acetoxy)propanol (927826-30-0) → 3-acetoxy-2-benzyloxycarbonylamino-2-methyl-propionic acid

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / -60 - 20 °C

2: NaClO₂; 2-methyl-2-butene; NaH₂PO₄*2H₂O / 2-methyl-propan-2-ol; H₂O / 1 h / 20 °C

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; water; tert-butyl alcohol;

DOI:10.1021/ol063063g

upstream raw materials:

benzyl chloroformate