(8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Base Information

Chemical Name:(8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione
CAS No.:349465-30-1
Molecular Formula:C₂₀H₂₄N₂O₂
Molecular Weight:324.423
Hs Code.:

Synonyms:(8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

There total 3 articles about (8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 79164-15-1
3,3-dimethyl-2-phenyl-pent-4-enal

: 114604-94-3
(8αS)-(1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-yl)-phosphonic acid dimethyl ester

: (S)-3-[3,3-Dimethyl-2-phenyl-pent-4-en-(E)-ylidene]-hexahydro-pyrrolo[1,2-a]pyrazine-1,4-dione

: 349465-30-1
(8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: (8αS)-(1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-yl)-phosphonic acid dimethyl ester; With potassium tert-butylate; In dichloromethane; tert-butyl alcohol; at -78 ℃; for 0.25h;

3,3-dimethyl-2-phenyl-pent-4-enal; In dichloromethane; tert-butyl alcohol; at -78 - 20 ℃; Further stages.;
DOI:10.1021/jo0100897

Reference yield:

: 556-82-1
3-methyl-2-buten-1-ol

: 349465-30-1
(8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / o-nitrobenzoic acid / 1,3,5-trimethyl-benzene / Heating

2.1: t-BuOK / CH₂Cl₂; 2-methyl-propan-2-ol / 0.25 h / -78 °C

2.2: 51 percent / CH₂Cl₂; 2-methyl-propan-2-ol / -78 - 20 °C

With ortho-nitrobenzoic acid; potassium tert-butylate; In dichloromethane; tert-butyl alcohol; 1,3,5-trimethyl-benzene;
DOI:10.1021/jo0100897

Reference yield:

: 101-48-4
phenylacetaldehyde dimethyl acetal

: 349465-30-1
(8aS)-3(Z)-(3,3-dimethyl-2-phenyl-4-pentenylidene)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: 77 percent / o-nitrobenzoic acid / 1,3,5-trimethyl-benzene / Heating

2.1: t-BuOK / CH₂Cl₂; 2-methyl-propan-2-ol / 0.25 h / -78 °C

2.2: 51 percent / CH₂Cl₂; 2-methyl-propan-2-ol / -78 - 20 °C

With ortho-nitrobenzoic acid; potassium tert-butylate; In dichloromethane; tert-butyl alcohol; 1,3,5-trimethyl-benzene;
DOI:10.1021/jo0100897