1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethanone

Base Information

• Chemical Name: 1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethanone
• CAS No.: 213408-28-7
• Molecular Formula: C₂₂H₃₁NO₃S
• Molecular Weight: 389.559
• Mol file: 213408-28-7.mol

Synonyms:1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethanone

Chemical Property of 1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethanone

There total 1 articles about 1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradeca-1(14),2-dien-2-yl]ethanone → 1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1(14)-en-2-yl]ethanone (213408-28-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tri-n-butyl-tin hydride; acetic acid; In benzene; for 3h; Ambient temperature;

DOI:10.1021/ja981183g

Reference yield: 90.0%

1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1(14)-en-2-yl]ethanone (213408-28-7) → 1-[12-(Toluene-4-sulfonyl)-12-aza-bicyclo[9.2.1]tetradec-1(14)-en-2-yl]-ethanol (213408-45-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether;

DOI:10.1021/ja981183g

Reference yield:

1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1(14)-en-2-yl]ethanone (213408-28-7) → 2-ethyl-12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1(14)-ene (213408-31-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / LiAlH₄ / diethyl ether

2: 63 percent / pyridine / CH₂Cl₂ / 20 h / Ambient temperature

3: 93 percent / AIBN, n-Bu₃SnH / toluene / 4 h / 75 °C

With pyridine; lithium aluminium tetrahydride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In diethyl ether; dichloromethane; toluene;

DOI:10.1021/ja981183g

Downstream raw materials:

1-[12-(Toluene-4-sulfonyl)-12-aza-bicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]-ethanol

2-ethyl-12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-ene

thiocarbonic acid O-phenyl ester O-{1-[12-(toluene-4-sulfonyl)-12-azabicyclo[9.2.1]tetradec-1⁽¹⁴⁾-en-2-yl]ethyl} ester