(+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.0^3',7'>undecanylidene>ethanoate

Base Information

• Chemical Name: (+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.0^3',7'>undecanylidene>ethanoate
• CAS No.: 163230-60-2
• Molecular Formula: C₄₀H₅₉NO₇SSi
• Molecular Weight: 726.062

Synonyms:(+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.0^3',7'>undecanylidene>ethanoate

Chemical Property of (+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.0^3',7'>undecanylidene>ethanoate

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Technology Process of (+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.0^3',7'>undecanylidene>ethanoate

There total 1 articles about (+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.0^3',7'>undecanylidene>ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(1S)-1-Cyclohexyl-1-(tetrahydropyran-2-yloxy)-2-propyne + (+)-Ethyl (2E)-2-<(3'S)-2'-aza-2'-<(1''S,4'R)-4''-<(tert-butyldimethylsilyl)oxy>-2''-(phenylsulfonyl)-2''-cyclopentenyl>-3'-(chloromethyl)cyclopentylidene>ethanoate → (+)-Ethyl (2E)-2-<(3'S,5'R,6'(1''S),9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>tricyclo<6.3.0.03',7'>undeca-6-enylidene>ethanoate + (+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.03',7'>undecanylidene>ethanoate (163230-60-2)

Guidance literature:

With n-butyllithium; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; 1.) 0 deg C, 10 min, 2.) -30 deg C, 15 min;

DOI:10.1021/jo00114a016

Reference yield: 88.0%

(+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.03',7'>undecanylidene>ethanoate (163230-60-2) → (+)-Ethyl (2E)-2-<(3'S,5'R,6'(1''S),9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>tricyclo<6.3.0.03',7'>undeca-6-enylidene>ethanoate

Guidance literature:

With disodium hydrogenphosphate; sodium amalgam; ethanol; 1.) 0 deg C, 1 h, 2.) r.t., overnight;

DOI:10.1021/jo00114a016

Reference yield: 78.0%

(+)-Ethyl (2E)-2-<(3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.03',7'>undecanylidene>ethanoate (163230-60-2) → (-)-Ethyl 2-<(1'S,3'S,5'R,6'S(1''S),7'S,9'S)-2'-aza-5'-<(tert-butyldimethylsilyl)oxy>-6'-<1''-cyclohexyl-1''-(tetrahydropyranyloxy)prop-2''-yn-3''-yl>-7'-(phenylsulfonyl)tricyclo<6.3.0.03',7'>undecanyl>ethanoate

Guidance literature:

With sodium cyanoborohydride; acetic acid; In ethanol; for 4h;

DOI:10.1021/jo00114a016

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