methyl 2-(3-phenoxybenzylamino)acetate

Base Information

• Chemical Name: methyl 2-(3-phenoxybenzylamino)acetate
• CAS No.: 1019577-16-2
• Molecular Formula: C₁₆H₁₇NO₃
• Molecular Weight: 271.316
• Mol file: 1019577-16-2.mol

Synonyms:methyl 2-(3-phenoxybenzylamino)acetate

Chemical Property of methyl 2-(3-phenoxybenzylamino)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(3-phenoxybenzylamino)acetate

There total 3 articles about methyl 2-(3-phenoxybenzylamino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

glycine ethyl ester hydrochloride (5680-79-5,883886-67-7) + 3-Phenoxybenzaldehyde (39515-51-0) → methyl 2-(3-phenoxybenzylamino)acetate (1019577-16-2)

Guidance literature:

glycine ethyl ester hydrochloride; With triethylamine; In methanol; for 0.166667h; Inert atmosphere;

3-Phenoxybenzaldehyde; In methanol; at 0 ℃; for 4h; Inert atmosphere;

With sodium tetrahydroborate; In methanol; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.08.032

Reference yield:

C16H15NO3 → methyl 2-(3-phenoxybenzylamino)acetate (1019577-16-2)

Guidance literature:

With sodium cyanoborohydride; In methanol; at 20 ℃; for 2h;

DOI:10.1021/jm500681z

Reference yield:

3-Phenoxybenzaldehyde (39515-51-0) → methyl 2-(3-phenoxybenzylamino)acetate (1019577-16-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic acid / methanol / 0.25 h / 20 °C / Molecular sieve

2: sodium cyanoborohydride / methanol / 2 h / 20 °C

With sodium cyanoborohydride; acetic acid; In methanol;

DOI:10.1021/jm500681z

upstream raw materials:

glycine ethyl ester hydrochloride

3-Phenoxybenzaldehyde

Downstream raw materials:

methyl 2-((N-(tert-butoxycarbonyl)sulfamoyl)(3-phenoxybenzyl)amino)acetate

methyl 2-((3-phenoxybenzyl)(sulfamoyl)amino)acetate

Refernces

• 1、 Dou, Dengfeng,Mandadapu, Sivakoteswara Rao,Alliston, Kevin R.,Kim, Yunjeong,Chang, Kyeong-Ok,Groutas, William C.. "Design and synthesis of inhibitors of noroviruses by scaffold hopping". experimental part. p. 5749 - 5755. Retrieved 2011/10/31.