3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione

Base Information

• Chemical Name: 3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione
• CAS No.: 878419-33-1
• Molecular Formula: C₁₂H₈FN₅O₂
• Molecular Weight: 273.226

Synonyms:3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione

Chemical Property of 3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione

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Technology Process of 3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione

There total 1 articles about 3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

C13H12FN5O4 (1207462-61-0) → 3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione (878419-33-1)

Guidance literature:

With ammonium chloride; zinc; In water; N,N-dimethyl-formamide; In air; Reflux;

DOI:10.1055/s-0029-1217030

Reference yield: 91.0%

3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione (878419-33-1) + alpha-bromo-3,4-difluorotoluene (85118-01-0) → 8-(3,4-difluorobenzyl)-3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione (1207377-90-9)

Guidance literature:

With caesium carbonate; In acetone; at 20 ℃; regiospecific reaction; In sealed vessel;

DOI:10.1055/s-0029-1217030

Reference yield: 71.0%

3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione (878419-33-1) + 1-(bromomethyl)-4-(1,1-dimethylethyl)benzene (18880-00-7) → 8-(4-tert-butylbenzyl)-3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione (1207377-82-9)

Guidance literature:

With caesium carbonate; In acetone; at 20 ℃; regiospecific reaction; In sealed vessel;

DOI:10.1055/s-0029-1217030

upstream raw materials:

C₁₃H₁₂FN₅O₄

Downstream raw materials:

8-(4-tert-butylbenzyl)-3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione

8-(3,4-difluorobenzyl)-3-(4-fluorophenyl)-6-methylpyrimido[5,4-e][1,2,4]triazine-5,7(6H,8H)-dione

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