(6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

Base Information

Chemical Name:(6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine
CAS No.:76222-40-7
Molecular Formula:C₃₅H₃₈N₂O₆S₂
Molecular Weight:646.829
Hs Code.:

Synonyms:(6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

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Chemical Property of (6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

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Technology Process of (6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

There total 6 articles about (6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 76222-41-8,76222-42-9
(5S,6S)-5-bromo-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

: 76222-40-7
(6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

Guidance literature:: With nickel; In tetrahydrofuran; ethanol; at 90 ℃; for 1h;
DOI:10.1016/S0008-6215(00)84560-7

Reference yield: 33.0%

: 76222-41-8,76222-42-9
(5R,6S)-5-bromo-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

: 76222-40-7
(6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

Guidance literature:: With nickel; In tetrahydrofuran; ethanol; at 90 ℃; for 1h;
DOI:10.1016/S0008-6215(00)84560-7

Reference yield:

: 76-83-5
trityl chloride

: 76222-40-7
(6R)-5,6-dihydro-6-(1,3-dithian-2-yl)-2',3'-O-isopropylidene-5'-O-trityluridine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / pyridine / 4 h / 100 °C

2: 1.) butyllithium / 1.) tetrahydrofuran, hexane, 30 min, -78 degC, then 4 h, -20 degC; 2.) pyridine, 24 h, -20 degC

With n-butyllithium; In pyridine;
DOI:10.1016/S0008-6215(00)84560-7