S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

Base Information

Chemical Name:S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate
CAS No.:1403986-91-3
Molecular Formula:C₂₃H₂₉NO₄S
Molecular Weight:415.554
Hs Code.:

Synonyms:S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

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Chemical Property of S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

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Technology Process of S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

There total 5 articles about S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1403986-87-7
(2E,4S,5S,6R,7R,8E)-S-p-tolyl 7-((dimethyl)(1,1-dimethylethyl)silyloxy)-5-hydroxy-4,6,8-trimethyl-9-(2-methyloxazol-4-yl)nona-2,8-dienethioate

: 1403986-91-3
S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

Guidance literature:: With camphor-10-sulfonic acid; In methanol; 1,2-dichloro-ethane; at 20 - 55 ℃;
DOI:10.1021/ol3026523

Reference yield:

: 872827-92-4
S-(4-methylphenyl) 2-propenethioate

: 1403986-91-3
S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; Hoveyda-Grubbs catalyst second generation / diethyl ether / 3 h / Inert atmosphere; Reflux

2: camphor-10-sulfonic acid / 1,2-dichloro-ethane; methanol / 20 - 55 °C

With copper(l) iodide; Hoveyda-Grubbs catalyst second generation; camphor-10-sulfonic acid; In methanol; diethyl ether; 1,2-dichloro-ethane;
DOI:10.1021/ol3026523

Reference yield:

: 1403986-85-5
(3S,4S,5R,6R,E)-6-((dimethyl)(1,1-dimethylethyl)silyloxy)-3,5,7-trimethyl-8-(2-methyloxazol-4-yl)octa-1,7-dien-4-ol

: 1403986-91-3
S-4-methylphenyl 2-((2R,3R,4S,5R,6R)-tetrahydro-4-hydroxy-3,5-dimethyl-6-((E)-1-(2-methyloxazol-4-yl)prop-1-en-2-yl)-2H-pyran-2-yl)ethanethioate

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; Hoveyda-Grubbs catalyst second generation / diethyl ether / 3 h / Inert atmosphere; Reflux

2: camphor-10-sulfonic acid / 1,2-dichloro-ethane; methanol / 20 - 55 °C

With copper(l) iodide; Hoveyda-Grubbs catalyst second generation; camphor-10-sulfonic acid; In methanol; diethyl ether; 1,2-dichloro-ethane;
DOI:10.1021/ol3026523