(3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

Base Information

Chemical Name:(3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester
CAS No.:855231-19-5
Molecular Formula:C₃₄H₃₇FN₂O₅
Molecular Weight:572.677
Hs Code.:

Synonyms:(3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

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Chemical Property of (3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

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Technology Process of (3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

There total 10 articles about (3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 855231-17-3
(3R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3-hydroxy-5-oxo-heptanoic acid methyl ester

: 855231-19-5
(3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

Guidance literature:: (3R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3-hydroxy-5-oxo-heptanoic acid methyl ester; With diethyl methoxy borane; In tetrahydrofuran; methanol; at -78 ℃; for 0.5h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; for 2h;

With acetic acid; In tetrahydrofuran; methanol;

Reference yield:

: 950599-93-6
(3R,5S)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyhept-6-enoic acid methyl ester

: 855231-19-5
(3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; ethanol; at 25 ℃; for 3h;
DOI:10.1016/j.bmcl.2007.05.096

Reference yield:

: 855231-02-6
4-(4-fluoro-phenyl)-1-isopropyl-3-phenyl-1H-pyrrole-2-carboxylic acid ethyl ester

: 855231-19-5
(3R,5R)-7-[3-(4-fluorophenyl)-1-isopropyl-4-phenyl-5-phenylcarbamoyl-1H-pyrrol-2-yl]-3,5-dihydroxyheptanoic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: POCl₃ / 1,2-dichloro-ethane / 3 h / 80 °C

2: 100 percent / NaOH / methanol / 2 h / 60 °C

3: SOCl₂ / 80 °C

4: Et₃N / tetrahydrofuran / 12 h / 25 °C

5: toluene / 48 h / 110 °C

6: aq. HF / acetonitrile / 2 h / 0 °C

7: Et₂B(OMe); NaBH₄; AcOH / tetrahydrofuran / 2 h / -78 °C

8: H₂ / Pd/C / ethanol; tetrahydrofuran / 3 h / 25 °C

With sodium hydroxide; sodium tetrahydroborate; thionyl chloride; diethyl methoxy borane; hydrogen fluoride; hydrogen; acetic acid; triethylamine; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 1,2-dichloro-ethane; toluene; acetonitrile; 1: Vilsmeir-Haack reaction / 5: Wittig olefination;
DOI:10.1016/j.bmcl.2007.05.096