1-benzyl 6-tert-butyl-3-oxohexanedioate

Base Information

Chemical Name:1-benzyl 6-tert-butyl-3-oxohexanedioate
CAS No.:419542-85-1
Molecular Formula:C₁₇H₂₂O₅
Molecular Weight:306.359
Hs Code.:

Synonyms:1-benzyl 6-tert-butyl-3-oxohexanedioate

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Chemical Property of 1-benzyl 6-tert-butyl-3-oxohexanedioate

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Technology Process of 1-benzyl 6-tert-butyl-3-oxohexanedioate

There total 5 articles about 1-benzyl 6-tert-butyl-3-oxohexanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 419542-85-1
1-benzyl 6-tert-butyl-3-oxohexanedioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran; hexane / -70 °C

1.2: 67.6 percent / tetrahydrofuran; hexane / 0.5 h / -100 °C

2.1: 84.5 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

3.1: tetrahydrofuran / 0.17 h / 20 °C

4.1: LDA / tetrahydrofuran; hexane / 0.08 h / -70 °C

4.2: 3.83 g / tetrahydrofuran; hexane / 0.08 h / -70 °C

With hydrogen; lithium diisopropyl amide; 10percent Pd/C; In tetrahydrofuran; hexane;
DOI:10.1021/ja016965f

Reference yield:

: 15026-16-1
1-benzyl 4-tert-butyl succinate

: 419542-85-1
1-benzyl 6-tert-butyl-3-oxohexanedioate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 84.5 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 3 h

2.1: tetrahydrofuran / 0.17 h / 20 °C

3.1: LDA / tetrahydrofuran; hexane / 0.08 h / -70 °C

3.2: 3.83 g / tetrahydrofuran; hexane / 0.08 h / -70 °C

With hydrogen; lithium diisopropyl amide; 10percent Pd/C; In tetrahydrofuran; hexane;
DOI:10.1021/ja016965f

Reference yield:

: 140-11-4
Benzyl acetate

: 4-imidazol-1-yl-4-oxo-butyric acid tert-butyl ester

: 419542-85-1
1-benzyl 6-tert-butyl-3-oxohexanedioate

Guidance literature:: Benzyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -70 ℃; for 0.0833333h;

4-imidazol-1-yl-4-oxo-butyric acid tert-butyl ester; In tetrahydrofuran; hexane; at -70 ℃; for 0.0833333h; Further stages.;
DOI:10.1021/ja016965f