1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Base Information

Chemical Name:1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate
CAS No.:1256959-09-7
Molecular Formula:C₂₈H₂₉N₅O₅
Molecular Weight:515.569
Hs Code.:

Synonyms:1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

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Chemical Property of 1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

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Technology Process of 1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

There total 7 articles about 1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1256959-08-6
1,1-dimethylethyl 7-(5,6-diaminopyridin-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

: 25508-20-7
N,N'-dibenzyloxycarbonyl-(S)-methyl-isothiourea

: 1256959-09-7
1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Guidance literature:: In acetic acid; at 50 ℃; for 4h;

Reference yield:

: 1761-61-1
5-bromosalicyclaldehyde

: 1256959-09-7
1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 40 °C

1.2: 20 °C

2.1: triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane / 12 h / 20 °C

3.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexanes / 1.17 h / -78 °C

3.2: 20 °C

4.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 90 °C / Inert atmosphere

5.1: hydrogen; acetic acid / palladium on activated charcoal / 1 h / 2327.23 Torr

6.1: acetic acid / 3 h / 86 °C

With methanol; sodium tetrahydroborate; n-butyllithium; Triisopropyl borate; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; acetic acid; triphenylphosphine; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water;

Reference yield:

: 740842-73-3
1,1-dimethylethyl 7-bromo-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

: 1256959-09-7
1,1-dimethylethyl-7-[2-({[(phenylmethyl)oxy]carbonyl}amino)-1H-imidazo[4,5-b]pyridine-6-yl]-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexanes / 1.17 h / -78 °C

1.2: 20 °C

2.1: caesium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 90 °C / Inert atmosphere

3.1: hydrogen; acetic acid / palladium on activated charcoal / 1 h / 2327.23 Torr

4.1: acetic acid / 3 h / 86 °C

With n-butyllithium; Triisopropyl borate; hydrogen; caesium carbonate; acetic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; hexanes; water;