2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

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Chemical Name:2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile
CAS No.:1413912-87-4
Molecular Formula:C₂₆H₂₉N₇O₂
Molecular Weight:471.562
Hs Code.:

Synonyms:2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

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Chemical Property of 2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

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Technology Process of 2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

There total 7 articles about 2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1413912-93-2
2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

: 1413912-87-4
2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

Guidance literature:: 2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5-((2-(trimethylsilyl)ethoxy)methyl)-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile; With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

With sodium hydrogencarbonate;

Reference yield:

: 875781-41-2
5-bromo-3-((trimethylsilyl)ethynyl)pyrazine-2-amine

: 1413912-87-4
2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran / 1.83 h / 20 - 65 °C / Inert atmosphere

2.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

2.2: 21.17 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

3.2: 0.5 h / 0 - 20 °C

4.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

4.2: 4 h / 110 °C

5.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

6.1: piperidinyl acetate / ethanol; water / 16 h / 20 - 80 °C

7.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With piperidinyl acetate; diethyl aluminiumcholoride; potassium tert-butylate; sodium hydride; caesium carbonate; pyridinium chlorochromate; trifluoroacetic acid; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; paraffin oil;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1413912-87-4
2-(4-methylpiperazine-1-carbonyl)-3-(4-(7-pivaloyl-5H-pyrrolo[2,3-b]pyrazin-2-ylamino)phenyl)acrylonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethyl aluminiumcholoride / dichloromethane; hexane / 0.5 h / 0 °C / Inert atmosphere

1.2: 21.17 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; paraffin oil / 0.42 h / 0 °C

2.2: 0.5 h / 0 - 20 °C

3.1: caesium carbonate / toluene / 0.75 h / 20 °C / Sealed tube; Inert atmosphere

3.2: 4 h / 110 °C

4.1: pyridinium chlorochromate / dichloromethane / 2 h / 5 - 20 °C / Inert atmosphere

5.1: piperidinyl acetate / ethanol; water / 16 h / 20 - 80 °C

6.1: trifluoroacetic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With piperidinyl acetate; diethyl aluminiumcholoride; sodium hydride; caesium carbonate; pyridinium chlorochromate; trifluoroacetic acid; In ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; paraffin oil;