(4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione

Base Information

• Chemical Name: (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione
• CAS No.: 104499-18-5
• Molecular Formula: C₁₄H₁₅NO₂S
• Molecular Weight: 261.345
• Mol file: 104499-18-5.mol

Synonyms:(4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione

Chemical Property of (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione

There total 4 articles about (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.4%

trans-chrotonyl chloride (625-35-4,3488-22-0,10487-71-5) + (4R,5S)-(+)-4-methyl-5-phenyl-1,3-oxazolidine-2-thione (91794-28-4) → (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione (104499-18-5)

Guidance literature:

With pyridine; In benzene; for 2h; Ambient temperature;

Reference yield:

(4R,5S)-3-benzoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione (104499-16-3) → (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione (104499-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / tetrahydrofuran; H₂O / 0.5 h / Ambient temperature

2: 61.4 percent / pyridine / benzene / 2 h / Ambient temperature

With pyridine; sodium tetrahydroborate; In tetrahydrofuran; water; benzene;

Reference yield:

Acutrim (40626-29-7) → (4R,5S)-3-crotonoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione (104499-18-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 73.1 percent / Et₃N / CH₂Cl₂ / Ambient temperature

2: 61.4 percent / pyridine / benzene / 2 h / Ambient temperature

With pyridine; triethylamine; In dichloromethane; benzene;

upstream raw materials:

trans-chrotonyl chloride

(4R,5S)-(+)-4-methyl-5-phenyl-1,3-oxazolidine-2-thione

Acutrim

(4R,5S)-3-propanoyl-4-methyl-5-phenyl-1,3-oxazolidine-2-thione

Downstream raw materials:

1-((4R,5S)-4-Methyl-5-phenyl-2-thioxo-oxazolidin-3-yl)-3-phenylsulfanyl-butan-1-one