Technology Process of C16H22O3
There total 9 articles about C16H22O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
water; calcium carbonate; methyl iodide;
In
acetonitrile;
at 40 ℃;
for 24h;
Inert atmosphere;
DOI:10.1021/ol2007296
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 0.5h;
DOI:10.1021/ol1023008
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 3 h / 0 °C / Inert atmosphere
2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -20 °C / Inert atmosphere
2.2: -78 °C / Inert atmosphere
3.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere
3.2: 4 h / 0 °C / Inert atmosphere
4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
5.1: sulfur trioxide pyridine complex; triethylamine / dichloromethane; dimethyl sulfoxide / 2 h / 0 °C / Inert atmosphere
6.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
6.2: 0 °C / Inert atmosphere
7.1: water; calcium carbonate; methyl iodide / acetonitrile / 24 h / 40 °C / Inert atmosphere
With
n-butyllithium; tetrabutyl ammonium fluoride; water; sodium hexamethyldisilazane; sulfur trioxide pyridine complex; sodium hydride; triethylamine; calcium carbonate; methyl iodide;
In
tetrahydrofuran; hexane; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile; mineral oil;
6.2: Wittig reaction;
DOI:10.1021/ol2007296
