ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

Base Information

Chemical Name:ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate
CAS No.:1235477-31-2
Molecular Formula:C₂₂H₂₇N₃O₆
Molecular Weight:429.473
Hs Code.:

Synonyms:ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

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Chemical Property of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

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Technology Process of ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

There total 4 articles about ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 39256-85-4
ethyl 2-amino-L-butyrate

: 1235477-26-5
2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)acetic acid

: 1235477-31-2
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1007/s00706-010-0280-x

Reference yield:

: 1215293-89-2
3-benzyl-4-imino-2-oxo-1,2,3,4-tetrahydro-5-acetylpyrimidine

: 1235477-31-2
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: water; acetic acid / 110 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

3: water; sodium hydroxide / tetrahydrofuran / 50 °C

4: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 0 - 5 °C

5: tetrahydrofuran / 7 h / Reflux

With water; potassium carbonate; acetic acid; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00706-010-0280-x

Reference yield:

: 1235477-17-4
ethyl 2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxypyrimidin-1(2H)-yl)acetate

: 1235477-31-2
ethyl 2-[[2-(5-acetyl-3-benzyl-3,4-dihydro-2,4-dioxopyrimidin-1(2H)-yl)-1-oxoethyl]amino]pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: water; sodium hydroxide / tetrahydrofuran / 50 °C

2: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 0 - 5 °C

3: tetrahydrofuran / 7 h / Reflux

With water; dicyclohexyl-carbodiimide; sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s00706-010-0280-x