N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

Base Information

Chemical Name:N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide
CAS No.:1453173-62-0
Molecular Formula:C₂₅H₃₁N₅O₅
Molecular Weight:481.552
Hs Code.:

Synonyms:N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

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Chemical Property of N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

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Technology Process of N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

There total 4 articles about N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.6%

: C₃₂H₃₅N₅O₅

: 1453173-62-0
N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 48h;
DOI:10.3390/molecules18066491

Reference yield:

: 1453173-50-6
ethyl (E)-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)acrylate

: 1453173-62-0
N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 13 h / -78 - 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C

With palladium 10% on activated carbon; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol;
DOI:10.3390/molecules18066491

Reference yield:

: 199327-59-8
4-chloro-7-methoxy-6-(3-morpholinopropoxy)quinazoline

: 1453173-62-0
N-hydroxy-3-(4-((7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-yl)amino)phenyl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: isopropyl alcohol / 5 h / Reflux

2: lithium hexamethyldisilazane / tetrahydrofuran / 13 h / -78 - 20 °C

3: palladium 10% on activated carbon; hydrogen / methanol / 48 h / 20 °C

With palladium 10% on activated carbon; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.3390/molecules18066491