3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane

Base Information

• Chemical Name: 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane
• CAS No.: 344357-97-7
• Molecular Formula: C₁₉H₃₀O₃Si₂
• Molecular Weight: 362.616
• Mol file: 344357-97-7.mol

Synonyms:3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane

Chemical Property of 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane

There total 3 articles about 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-((Z)-3-dimethylphenylsilyl-2-formylprop-2-enyl)-5-exo-(formylmethylene)-1,1-dimethyl-2-oxa-1-silacyclopentane → 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane (344357-97-7)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 0 ℃; for 0.75h;

DOI:10.1021/ol0156594

Reference yield:

Dimethylphenylsilane (766-77-8) → 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane (344357-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent Chromat_. / Rh(acac)(CO)2 / toluene / 8 h / 20 °C / 7600.51 Torr

2: 56 percent / NaBH₄ / methanol / 0.75 h / 0 °C

With sodium tetrahydroborate; acetylacetonatodicarbonylrhodium(l); In methanol; toluene;

DOI:10.1021/ol0156594

Reference yield:

4-dimethylsilyloxy-1,6-heptadiyne → 3-(3-dimethylphenylsilyl-2-hydroxymethylprop-2-enyl)-5-exo-hydroxyethylidene-1,1-dimethyl-2-oxa-1-silacyclopentane (344357-97-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent Chromat_. / Rh(acac)(CO)2 / toluene / 8 h / 20 °C / 7600.51 Torr

2: 56 percent / NaBH₄ / methanol / 0.75 h / 0 °C

With sodium tetrahydroborate; acetylacetonatodicarbonylrhodium(l); In methanol; toluene;

DOI:10.1021/ol0156594

upstream raw materials:

Dimethylphenylsilane