Technology Process of 4-fluoro-1-(4-methoxybenzyl)-3-(β-D-xylopyranosyl)-1Hindole
There total 10 articles about 4-fluoro-1-(4-methoxybenzyl)-3-(β-D-xylopyranosyl)-1Hindole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol;
at 20 ℃;
for 1.5h;
under 760.051 Torr;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: potassium hydroxide / tetrahydrofuran; ethanol / 20 h / 0 - 60 °C
2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 16 h / 0 - 20 °C
3: palladium 10% on activated carbon / methanol; tetrahydrofuran / 1.5 h / 20 °C / 760.05 Torr / Inert atmosphere
With
palladium 10% on activated carbon; sodium hydride; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; mineral oil;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / tetrahydrofuran; toluene / 0.5 h / -78 °C / Inert atmosphere
1.2: 2 h / 20 °C
2.1: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 1 h / 0 - 20 °C / Inert atmosphere
3.1: potassium hydroxide / tetrahydrofuran; ethanol / 20 h / 0 - 60 °C
4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 16 h / 0 - 20 °C
5.1: palladium 10% on activated carbon / methanol; tetrahydrofuran / 1.5 h / 20 °C / 760.05 Torr / Inert atmosphere
With
triethylsilane; n-butyllithium; palladium 10% on activated carbon; boron trifluoride diethyl etherate; sodium hydride; potassium hydroxide;
In
tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;
