2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Base Information

Chemical Name:2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide
CAS No.:1282461-33-9
Molecular Formula:C₂₅H₂₅F₂N₅O₅S₂
Molecular Weight:577.633
Hs Code.:

Synonyms:2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

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Chemical Property of 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

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Technology Process of 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

There total 8 articles about 2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3537-14-2
5-nitro-pyridine-2,3-diamine

: 1282461-33-9
2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / Reflux

2: ammonium chloride; zinc / water; ethanol

3: trimethylaluminum / toluene / 90 °C

With trimethylaluminum; ammonium chloride; zinc; trichlorophosphate; In ethanol; water; toluene;
DOI:10.1016/j.bmcl.2013.08.086

Reference yield:

: 896114-83-3
2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine

: 1186193-95-2
methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate

: 1282461-33-9
2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Guidance literature:: 2-phenyl-3H-imidazo[4,5-b]pyridin-6-ylamine; With trimethylaluminum; In toluene; at 20 ℃; for 0.333333h;

methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate; In toluene; at 90 ℃; for 4h;

Reference yield:

: 83141-10-0
2,6-difluoro-3-nitrobenzoic acid

: 1282461-33-9
2,6-difluoro-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-3-(N-(propylsulfonyl)propylsulfonamido)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; hexane / 2 h / Cooling with cold water

2.1: hydrogen / palladium 10% on activated carbon / ethanol

3.1: triethylamine / dichloromethane / 20 °C / Cooling with water bath

4.1: trimethylaluminum / toluene / 0.33 h / 20 °C

4.2: 4 h / 90 °C

With hydrogen; trimethylaluminum; triethylamine; palladium 10% on activated carbon; In methanol; ethanol; hexane; dichloromethane; toluene;