(1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

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Chemical Name:(1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid
CAS No.:1383375-93-6
Molecular Formula:C₂₀H₁₇F₃N₆O₂
Molecular Weight:430.389
Hs Code.:

Synonyms:(1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

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Chemical Property of (1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

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Technology Process of (1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

There total 6 articles about (1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,3S)-ethyl 3-((5-cyano-4-(1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylate

: 1383375-93-6
(1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

Guidance literature:: (1R,3S)-ethyl 3-((5-cyano-4-(1-tosyl-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylate; With lithium hydroxide; In tetrahydrofuran; at 130 ℃; for 0.166667h; Microwave irradiation;

With hydrogenchloride; In water; at 20 ℃;

Reference yield:

: 53084-60-9,60601-06-1,62456-14-8
ethyl (1R,3S)-3-aminocyclohexanecarboxylate

: 1383375-93-6
(1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

2.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.35 h / 120 °C / Microwave irradiation

3.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 130 °C / Microwave irradiation

3.2: 20 °C

With sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; acetonitrile;

Reference yield:

: 227783-08-6
(1S,3R)-3-ethoxycarbonylcyclohexane-1-carboxylic acid

: 1383375-93-6
(1R,3S)-3-((5-cyano-4-(5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl)amino)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine; diphenyl phosphoryl azide / toluene / 1 h / 110 °C

1.2: 70 - 85 °C

2.1: hydrogen / palladium on activated charcoal / ethanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 20 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.35 h / 120 °C / Microwave irradiation

5.1: lithium hydroxide / tetrahydrofuran / 0.17 h / 130 °C / Microwave irradiation

5.2: 20 °C

With diphenyl phosphoryl azide; hydrogen; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; ethanol; toluene; acetonitrile;