(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

Base Information

Chemical Name:(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one
CAS No.:256326-88-2
Molecular Formula:C₄₀H₇₁N₅O₄SSi₂
Molecular Weight:774.272
Hs Code.:

(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

Synonyms:(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

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Chemical Property of (2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

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Technology Process of (2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

There total 1 articles about (2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 79271-56-0
triethylsilyl trifluoromethyl sulfonate

: 256326-87-1
(2S,3R,4S,5S,6R,9S,11S)-9-Ethyl-4-hydroxy-2-[(2S,3S)-2-hydroxy-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-hexyl]-3,5,11-trimethyl-1-oxa-7-aza-spiro[5.5]undecan-8-one

: 256326-88-2
(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

Guidance literature:: With pyridine; In acetonitrile; at -50 ℃; for 0.5h;
DOI:10.1021/jo9912395

Reference yield: 98.0%

: 256326-88-2
(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

: 256326-89-3
(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazole-5-sulfonyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

Guidance literature:: With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 14h;
DOI:10.1021/jo9912395

Reference yield:

: 256326-88-2
(2S,3S,4S,5S,6R,9S,11S)-9-Ethyl-3,5,11-trimethyl-2-[(2S,3S)-3-methyl-6-(1-phenyl-1H-tetrazol-5-ylsulfanyl)-2-triethylsilanyloxy-hexyl]-4-triethylsilanyloxy-1-oxa-7-aza-spiro[5.5]undecan-8-one

: 187148-13-6
(-)-sanglifehrin A

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / sodium bicarbonate; mCPBA / CH₂Cl₂ / 14 h / 20 °C

2: 49 percent / sodium bis(trimethylsilyl)amide / toluene / 8 h / -78 °C

3: 80 percent / TBAF / tetrahydrofuran / 72 h / 20 °C

4: 30 percent / TsOH; boric acid / tetrahydrofuran / 5 h / 20 °C

With tetrabutyl ammonium fluoride; boric acid; sodium hexamethyldisilazane; sodium hydrogencarbonate; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; toluene; 1: Oxidation / 2: Condensation / 3: Substitution / 4: Ring cleavage;
DOI:10.1021/jo9912395