1,3,4-Thiadiazole-2-sulfonamide, 5-(((4-aminophenyl)sulfonyl)amino)-

Base Information

• Chemical Name: 1,3,4-Thiadiazole-2-sulfonamide, 5-(((4-aminophenyl)sulfonyl)amino)-
• CAS No.: 3523-95-3
• Molecular Formula: C8H9 N5 O4 S3
• Molecular Weight: 335.389
• Hs Code.: 2935009090
• Mol file: 3523-95-3.mol

Synonyms:1,3,4-Thiadiazole-2-sulfonamide,5-sulfanilamido- (6CI,7CI,8CI); 2-(p-Aminobenzenesulfonamido)-1,3,4-thiadiazole-5-sulfonamide;5-[[(4-Aminophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide;Aminobenzolamide; CL 13475; NSC 700707

Chemical Property of 1,3,4-Thiadiazole-2-sulfonamide, 5-(((4-aminophenyl)sulfonyl)amino)-

Chemical Property:

• Vapor Pressure: 6.35E-17mmHg at 25°C
• Boiling Point: 652.8°Cat760mmHg
• Flash Point: 348.6°C
• PSA: 203.13000
• Density: 1.805g/cm³
• LogP: 3.08460

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,3,4-Thiadiazole-2-sulfonamide, 5-(((4-aminophenyl)sulfonyl)amino)-

There total 4 articles about 1,3,4-Thiadiazole-2-sulfonamide, 5-(((4-aminophenyl)sulfonyl)amino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-(4-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)acetamide (3523-96-4) → aminobenzolamide (3523-95-3)

Guidance literature:

N-(4-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)acetamide; With hydrogenchloride; In water; for 0.833333h; Reflux;

With ammonium hydroxide; In water; pH=9;

DOI:10.1016/j.bmc.2011.01.049

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) → aminobenzolamide (3523-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / 0.75 h / 100 °C

In hydrogenchloride;

Reference yield:

p-acetylaminobenzenesulfonyl chloride (121-60-8) → aminobenzolamide (3523-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NaOH / Ambient temperature

2: conc. HCl / 1 h / Heating

With hydrogenchloride; sodium hydroxide;

DOI:10.1016/S0223-5234(98)80042-1

upstream raw materials:

N-(4-(N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)sulfamoyl)phenyl)acetamide

p-acetylaminobenzenesulfonyl chloride

Downstream raw materials:

4,4'-(dithiodicarbonothioyl)dimorpholine