(3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

Base Information

Chemical Name:(3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole
CAS No.:1070764-13-4
Molecular Formula:C₂₂H₂₇NO
Molecular Weight:321.462
Hs Code.:

Synonyms:(3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

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Chemical Property of (3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

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Technology Process of (3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

There total 8 articles about (3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1070764-11-2
[(1S,2R,3R,4S)-4-hydroxy-3-(2-methylphenyl)cyclohexane-1,2-diyl]bis(methylene)dipropane-1-sulfonate

: 100-46-9
benzylamine

: 1070764-13-4
(3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

Guidance literature:: In ethanol; at 140 ℃; for 3h; Sealed tube;
DOI:10.1021/jm400751p

Reference yield:

: diethyl (1SR,2SR,3RS,4SR)-3-(2-methylphenyl)-4-hydroxycyclohexane-1,2-dicarboxylate

: 1070764-13-4
(3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

Guidance literature:: Multi-step reaction with 4 steps

1: CHIRACEL AD column / hexane; isopropyl alcohol / Resolution of racemate

2: lithium borohydride / tetrahydrofuran / 12 h / 0 - 75 °C / Inert atmosphere

3: 2,6-dimethylpyridine / dichloromethane; acetonitrile / 41 h / 20 °C

4: ethanol / 3 h / 140 °C / Sealed tube

With 2,6-dimethylpyridine; lithium borohydride; In tetrahydrofuran; ethanol; hexane; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm400751p

Reference yield:

: 1070764-09-8
(1S,2R,3R,4S)-3,4-bis(hydroxymethyl)-2-(2-methylphenyl)cyclohexanol

: 1070764-13-4
(3aR,4R,5S,7aS)-2-benzyl-5-hydroxy-4-(2-methylphenyl)octahydro-1H-isoindole

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane; acetonitrile / 41 h / 20 °C

2: ethanol / 3 h / 140 °C / Sealed tube

With 2,6-dimethylpyridine; In ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm400751p