3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester
CAS No.:206441-83-0
Molecular Formula:C₂₂H₃₇N₃O₅Si
Molecular Weight:451.638
Hs Code.:

3-<i>tert</i>-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

Synonyms:3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

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Chemical Property of 3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

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Technology Process of 3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

There total 2 articles about 3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 206441-79-4
6-amino-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methylbenzoic 2-(trimethylsilyl)ethyl ester

: 1795-48-8
Isopropyl isocyanate

: 206441-83-0
3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: With polymer-bound DMAP; In dichloromethane; at 55 ℃; for 49h;
DOI:10.1016/S0040-4020(98)00132-X

Reference yield:

: 185689-41-2
1,1-dimethylethyl(1,4-dihydro-5-methyl-2,4-dioxo-2H-3,1-benzoxazin-6-yl)carbamate

: 206441-83-0
3-tert-butoxycarbonylamino-6-(3-isopropyl-ureido)-2-methyl-benzoic acid 2-trimethylsilanyl-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / tetrahydrofuran / 3 h / Heating

1.2: 48 percent / tetrahydrofuran / 96 h / Heating

2.1: polymer-bound DMAP / CH₂Cl₂ / 49 h / 55 °C

With polymer-bound DMAP; potassium carbonate; In tetrahydrofuran; dichloromethane; 1.1: Metallation / 1.2: Ring cleavage / 2.1: Addition;
DOI:10.1016/S0040-4020(98)00132-X