N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea

Base Information

• Chemical Name: N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea
• CAS No.: 195451-17-3
• Molecular Formula: C₂₂H₂₇N₃O₄
• Molecular Weight: 397.474
• Mol file: 195451-17-3.mol

Synonyms:N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea

Chemical Property of N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea

There total 6 articles about N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2,2-diethoxyethyl)indoline-2,3-dione (159884-41-0) → N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea (195451-17-3) + 1-(2,2-diethoxyethyl)-3-(hydroxyimino)indolin-2-one

Guidance literature:

With sodium chloride; hydroxylamine hydrochloride; sodium acetate; In ethanol; water;

Reference yield:

1-(2,2-diethoxyethyl)-1H-indole-2,3-dione 3-(O-methyloxime) (159884-54-5) + p-Tolylisocyanate (622-58-2,374675-64-6) → N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea (195451-17-3)

Guidance literature:

1-(2,2-diethoxyethyl)-1H-indole-2,3-dione 3-(O-methyloxime); With hydrogen; palladium on activated charcoal; In acetonitrile; at 20 ℃; for 6h; atmospheric pressure;

p-Tolylisocyanate; In acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jo061541v

Reference yield:

indole-2,3-dione (91-56-5,1186480-61-4,84788-92-1) → N-[1-(2,2-diethoxyethyl)-2,3-dihydro-2-oxo-1H-indol-3-yl]-N'-(4-methylphenyl)urea (195451-17-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 100 percent / dipotassium hydrogen phosphate / methanol / 2 h / 20 °C

2.1: 127 g / potassium tert-butoxide / N,N-dimethyl-acetamide / 4 h / 110 °C

3.1: hydrogen / palladium on carbon / acetonitrile / 6 h / 20 °C / atmospheric pressure

3.2: 109 g / acetonitrile / 1 h / 20 °C

With dipotassium hydrogenphosphate; potassium tert-butylate; hydrogen; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide; acetonitrile;

DOI:10.1021/jo061541v

upstream raw materials:

1-(2,2-diethoxyethyl)-1H-indole-2,3-dione 3-(O-methyloxime)

p-Tolylisocyanate

indole-2,3-dione

1H-indole-2,3-dione 3-(O-methyloxime)

Downstream raw materials:

(+)-1-(2,2-diethoxyethyl)-3-((4-methylphenyl)-aminocarbonylmethyl)-3-(N'-(4-methylphenyl)ureido)indolin-2-one

AG 041R

[(R)-2-oxo-1-(2-oxo-ethyl)-3-(3-p-tolylureido)-2,3-dihydro-1H-indol-3-yl]-acetic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

[1-(2,2-diethoxy-ethyl)-2-oxo-3-(3-p-tolyl-ureido)-2,3-dihydro-1H-indol-3-yl]-acetic acid