4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

Base Information

Chemical Name:4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile
CAS No.:1203604-78-7
Molecular Formula:C₂₁H₁₈N₆OS
Molecular Weight:402.48
Hs Code.:

Synonyms:4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

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Chemical Property of 4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

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Technology Process of 4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

There total 8 articles about 4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1203604-78-7
4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

Guidance literature:

Reference yield:

: 1203605-41-7
4-(3-chloro-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

: 1204196-92-8
(5-methoxybenzothiazol-2-yl)methylamine hydrogen chloride

: 1203604-78-7
4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 - 85 ℃; Inert atmosphere;
DOI:10.1021/jm301499r

Reference yield:

: 854059-90-8
5-methoxybenzothiazole-2-carboxaldehyde

: 1203604-78-7
4-(3-{[(5-methoxy-1,3-benzothiazol-2-yl)methyl]amino}-1,2,4-triazin-5-yl)-3,5-dimethylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate; hydroxylamine hydrochloride / ethanol / 20 °C / Inert atmosphere

2.1: acetic acid; zinc / 3 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 50 - 85 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; acetic acid; N-ethyl-N,N-diisopropylamine; zinc; In ethanol; acetonitrile;
DOI:10.1021/jm301499r