(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

Base Information

Chemical Name:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester
CAS No.:96857-05-5
Molecular Formula:C₁₈H₂₃F₃O₄
Molecular Weight:360.373
Hs Code.:

Synonyms:(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

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Chemical Property of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

Chemical Property:

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Technology Process of (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

There total 11 articles about (S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20445-33-4,39637-99-5
(R)-methoxytrifluoromethylphenylacetyl chloride

: 84435-13-2
(+)-(2S)-2-hydroxyoctan-3-one

: 96857-05-5
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

Guidance literature:: (+)-(2S)-2-hydroxyoctan-3-one; With dmap; In dichloromethane; Inert atmosphere;

(R)-methoxytrifluoromethylphenylacetyl chloride; With pyridine; In dichloromethane; at 23 ℃; for 3h; stereoselective reaction; Inert atmosphere;
DOI:10.1055/s-0036-1588666

Reference yield:

: 3391-86-4
1-octen-3-ol

: 96857-05-5
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 83.5 percent / Ti(i-PrO)4, diisopropyl D-(-)-tartrate, t-BuOOH / CH₂Cl₂ / 14.5 h / -20 °C / op: 93.6percent

2: 83.6 percent / p-TsOH / Ambient temperature; opt.pur. of start. mat.: 93.6percent

3: 95.6 percent / LAH / diethyl ether / 1.) 0 to 5 deg C, 20 min; 2.) RT, 6 h

4: NaH (60percent in min. oil) / 1.) DMF, 1 h, 60 to 65 deg C 2.) 55 deg C, 2 d

5: 91.3 percent / 1N HCl / tetrahydrofuran / 2 h / Ambient temperature

6: 82.8 percent / CrO₃, H₂SO₄ / acetone / 0.25 h / 0 °C

7: 59.2 percent / H₂O / 10percent-Pd/C / ethanol; H₂O / 760 Torr / op: 93.9percent

With chromium(VI) oxide; titanium(IV) isopropylate; hydrogenchloride; tert.-butylhydroperoxide; lithium aluminium tetrahydride; sulfuric acid; water; sodium hydride; D-(-)-diisopropyl tartrate; toluene-4-sulfonic acid; 10% palladium on active carbon; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; acetone;
DOI:10.1016/S0040-4020(01)96499-3

Reference yield:

: 89408-81-1,96856-99-4,98897-19-9,127996-51-4,127996-52-5,135637-52-4,135637-53-5,96856-96-1
(1R)-1-[(2S)-oxiran-2-yl]hexan-1-ol

: 96857-05-5
(S)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-1-methyl-2-oxo-heptyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 83.6 percent / p-TsOH / Ambient temperature; opt.pur. of start. mat.: 93.6percent

2: 95.6 percent / LAH / diethyl ether / 1.) 0 to 5 deg C, 20 min; 2.) RT, 6 h

3: NaH (60percent in min. oil) / 1.) DMF, 1 h, 60 to 65 deg C 2.) 55 deg C, 2 d

4: 91.3 percent / 1N HCl / tetrahydrofuran / 2 h / Ambient temperature

5: 82.8 percent / CrO₃, H₂SO₄ / acetone / 0.25 h / 0 °C

6: 59.2 percent / H₂O / 10percent-Pd/C / ethanol; H₂O / 760 Torr / op: 93.9percent

With chromium(VI) oxide; hydrogenchloride; lithium aluminium tetrahydride; sulfuric acid; water; sodium hydride; toluene-4-sulfonic acid; 10% palladium on active carbon; In tetrahydrofuran; diethyl ether; ethanol; water; acetone;
DOI:10.1016/S0040-4020(01)96499-3