2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Base Information

Chemical Name:2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole
CAS No.:1421869-16-0
Molecular Formula:C₂₉H₃₃N₇
Molecular Weight:479.628
Hs Code.:

Synonyms:2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

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Chemical Property of 2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

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Technology Process of 2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

There total 7 articles about 2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1451015-19-2
2-butyl-5-(diethylamino)-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole

: 1421869-16-0
2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Guidance literature:: With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 120 ℃; for 84h;
DOI:10.1007/s00044-012-0462-7

Reference yield:

: 109-52-4
valeric acid

: 1421869-16-0
2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1.1: trichlorophosphate / 3.5 h / 170 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 27 °C / Inert atmosphere

2.2: 12 h / 27 °C / Inert atmosphere

3.1: hydrogenchloride; tin(ll) chloride / ethanol / 70 °C

4.1: triethylamine / dichloromethane / Inert atmosphere

5.1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

6.1: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 84 h / 120 °C

With hydrogenchloride; sodium azide; potassium carbonate; ammonium chloride; triethylamine; tin(ll) chloride; trichlorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0462-7

Reference yield:

: 5-amino-2-butyl-1-[(2'-cyanobiphenyl-4-yl)methyl]-1H-benzimidazole

: 1421869-16-0
2-butyl-5-(diethylamino)-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / Inert atmosphere

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3: sodium azide; ammonium chloride / N,N-dimethyl-formamide / 84 h / 120 °C

With sodium azide; ammonium chloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1007/s00044-012-0462-7