(S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid

Base Information

• Chemical Name: (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid
• CAS No.: 205253-02-7
• Molecular Formula: C₁₆H₂₁N₃O₆
• Molecular Weight: 351.359
• Mol file: 205253-02-7.mol

Synonyms:(S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid

Chemical Property of (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid

There total 1 articles about (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

benzyl chloroformate (501-53-1,94274-21-2) + D-Ala-L-Gln (281660-34-2,656221-79-3,205252-36-4) → (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid (205253-02-7)

Guidance literature:

With sodium hydroxide; for 1.25h; Ambient temperature;

DOI:10.1021/jm970734v

Reference yield: 33.0%

2,3,4-tri-O-acetyl-β-L-fucopyranosylamine (169178-11-4) + (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid (205253-02-7) → Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(S)-2-((R)-2-benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyrylamino]-6-methyl-tetrahydro-pyran-3-yl ester (205253-03-8)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm970734v

Reference yield:

1-amino-2,3,4,6-tetra-O-acetyl-β-D-mannopyranosyl (41355-50-4) + (S)-2-((R)-2-Benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyric acid (205253-02-7) → Acetic acid (2R,3S,4S,5R,6R)-4,5-diacetoxy-6-acetoxymethyl-2-[(S)-2-((R)-2-benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyrylamino]-tetrahydro-pyran-3-yl ester

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm970734v

upstream raw materials:

benzyl chloroformate

D-Ala-L-Gln

Downstream raw materials:

Acetic acid (2S,3S,4R,5R,6S)-4,5-diacetoxy-2-[(S)-2-((R)-2-benzyloxycarbonylamino-propionylamino)-4-carbamoyl-butyrylamino]-6-methyl-tetrahydro-pyran-3-yl ester