(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

Base Information

Chemical Name:(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid
CAS No.:1400991-72-1
Molecular Formula:C₂₁H₂₂N₂O₅
Molecular Weight:382.416
Hs Code.:

Synonyms:(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

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Chemical Property of (S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

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Technology Process of (S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

There total 3 articles about (S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 60242-12-8
C₂₂H₂₄N₂O₅

: 1400991-72-1
(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

Guidance literature:: C₂₂H₂₄N₂O₅; With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=2;
DOI:10.1016/j.tet.2012.08.023

Reference yield:

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 1400991-72-1
(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 19 h / 0 - 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C

2.2: pH 2

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tet.2012.08.023

Reference yield:

: 15028-39-4,13226-98-7
L-2-phenylglycine methyl ester hydrochloride

: 1400991-72-1
(S)-2-[(S)-1-(benzyloxycarbonyl)pyrrolidine-2-carboxamido]-2-phenylacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide / dichloromethane / 19 h / 0 - 20 °C

2.1: sodium hydroxide / 1,4-dioxane; water / 1 h / 20 °C

2.2: pH 2

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; sodium hydroxide; In 1,4-dioxane; dichloromethane; water;
DOI:10.1016/j.tet.2012.08.023