pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide

Base Information

• Chemical Name: pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide
• CAS No.: 211745-86-7
• Molecular Formula: C₂₄H₂₉N₃O₄
• Molecular Weight: 423.512
• Mol file: 211745-86-7.mol

Synonyms:pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide

Chemical Property of pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide

There total 3 articles about pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

pent-4-enoic acid (591-80-0) + 2-[(benzylcarbamoyl-methyl)-amino]-N-(4-methoxy-benzyl)-acetamide; hydrochloride → pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide (211745-86-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃;

DOI:10.1016/S0040-4020(98)00128-8

Reference yield:

N-((tert-butyloxy)carbonyl)-N'-(benzyl)iminodiacetic acid monoamide (175353-91-0) → pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide (211745-86-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / i-Pr₂NEt; PyBOP / dimethylformamide / 25 °C

2: aq. HCl / dioxane / 4 h / 25 °C

3: 100 percent / i-Pr₂NEt; PyBrOP / dimethylformamide / 25 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis / 3: Acylation;

DOI:10.1016/S0040-4020(98)00128-8

Reference yield:

N-((tert-butyloxy)carbonyl)-N'-benzyl-N-(4-methoxybenzyl)iminodiacetic acid diamide (188625-19-6) → pent-4-enoic acid (benzylcarbamoyl-methyl)-[(4-methoxy-benzylcarbamoyl)-methyl]-amide (211745-86-7)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / dioxane / 4 h / 25 °C

2: 100 percent / i-Pr₂NEt; PyBrOP / dimethylformamide / 25 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In 1,4-dioxane; N,N-dimethyl-formamide; 1: Hydrolysis / 2: Acylation;

DOI:10.1016/S0040-4020(98)00128-8

upstream raw materials:

pent-4-enoic acid

N-((tert-butyloxy)carbonyl)-N'-(benzyl)iminodiacetic acid monoamide

N-((tert-butyloxy)carbonyl)-N'-benzyl-N-(4-methoxybenzyl)iminodiacetic acid diamide