Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester
• CAS No.: 112089-99-3
• Molecular Formula: C₄₅H₃₈N₆O₇S
• Molecular Weight: 806.899

Synonyms:Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Chemical Property of Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

There total 19 articles about Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-1H-indole-2-carboxylic acid ethyl ester (4993-93-5) → Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester (112089-99-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 83 percent / hydrogen / PtO₂ / ethanol; tetrahydrofuran / 3.25 h / 724.01 Torr

2: 81 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 48 h

3: 97 percent / aq. KOH / methanol; dimethylformamide / 0.5 h

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / dimethylformamide / 48 h

5: 51 percent / aq. KOH / dimethylformamide

6: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride

7: (dimethylamino)pyridine / pyridine

With dmap; potassium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; platinum(IV) oxide; In tetrahydrofuran; pyridine; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00398a017

Reference yield:

3-nitro-4-chlorophenol (610-78-6) → Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester (112089-99-3)

Guidance literature:

Multi-step reaction with 13 steps

1: 96 percent / K₂CO₃ / acetone; dimethylformamide / 64 h / Ambient temperature

2: 77 percent / NaH / dimethylsulfoxide / 24 h / 105 - 115 °C

3: 40 percent / diisobutylaluminum hydride / tetrahydrofuran / 2.3 h / Ambient temperature

4: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

5: 111 g / pyridine / 1.42 h / 5 °C

6: 1.) sodium acetate, 2.) triethylamine / 1.) ethanol, reflux, 20 h, 2.) methylene chloride

7: 64 percent / nitric acid / nitromethane / 0.67 h / 0 °C

8: 81 percent / hydrogen / 84.5percent PtO₂ / tetrahydrofuran; ethanol / 2 h / 2068.6 Torr

9: 1.) sulfuryl chloride, 2.) 1,8-bis(dimethylamino)naphthalene / 1.) methylene chloride, -70 deg C, 45 min, 2.) -70 deg C, 4 h

10: 90 percent / borane-methyl sulfide, 4-Angstroem molecular sieves / tetrahydrofuran / 3 h / Heating

11: sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene

12: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride

13: (dimethylamino)pyridine / pyridine

With pyridine; dmap; sulfuryl dichloride; dimethylsulfide borane complex; 4 A molecular sieve; hydrogen; nitric acid; sodium acetate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; sodium hydride; diisobutylaluminium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; platinum(IV) oxide; In tetrahydrofuran; pyridine; nitromethane; ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;

DOI:10.1021/jm00398a017

Reference yield:

2-[4-(benzyloxy)-2-nitrophenyl]propane-1,3-diol (106014-83-9) → Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester (112089-99-3)

Guidance literature:

Multi-step reaction with 10 steps

1: 69 percent / hydrogen / 84.5percent PtO₂ / ethanol / 2.75 h / 2327.2 Torr

2: 111 g / pyridine / 1.42 h / 5 °C

3: 1.) sodium acetate, 2.) triethylamine / 1.) ethanol, reflux, 20 h, 2.) methylene chloride

4: 64 percent / nitric acid / nitromethane / 0.67 h / 0 °C

5: 81 percent / hydrogen / 84.5percent PtO₂ / tetrahydrofuran; ethanol / 2 h / 2068.6 Torr

6: 1.) sulfuryl chloride, 2.) 1,8-bis(dimethylamino)naphthalene / 1.) methylene chloride, -70 deg C, 45 min, 2.) -70 deg C, 4 h

7: 90 percent / borane-methyl sulfide, 4-Angstroem molecular sieves / tetrahydrofuran / 3 h / Heating

8: sodium bis(2-methoxyethoxy)aluminum hydride / tetrahydrofuran; toluene

9: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride

10: (dimethylamino)pyridine / pyridine

With pyridine; dmap; sulfuryl dichloride; dimethylsulfide borane complex; 4 A molecular sieve; hydrogen; nitric acid; sodium acetate; N,N,N',N'-tetramethyl-1,8-diaminonaphthalene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; platinum(IV) oxide; In tetrahydrofuran; pyridine; nitromethane; ethanol; toluene;

DOI:10.1021/jm00398a017

upstream raw materials:

methanesulfonyl chloride

5-Benzoylamino-1H-indole-2-carboxylic acid [2-(5-benzyloxy-1-hydroxymethyl-8-methyl-1,6-dihydro-2H-pyrrolo[3,2-e]indole-3-carbonyl)-1H-indol-5-yl]-amide

3-nitro-4-chlorophenol

4-nitro-1H-indole-2-carboxylic acid ethyl ester

Downstream raw materials:

C₃₇H₂₈N₆O₄

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 112089-99-3 Methanesulfonic acid 3-{5-[(5-benzoylamino-1H-indole-2-carbonyl)-amino]-1H-indole-2-carbonyl}-5-benzyloxy-8-methyl-1,2,3,6-tetrahydro-pyrrolo[3,2-e]indol-1-ylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send