3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

Base Information

Chemical Name:3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one
CAS No.:1395316-26-3
Molecular Formula:C₂₀H₂₄BrNO₆
Molecular Weight:454.318
Hs Code.:

Synonyms:3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

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Chemical Property of 3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

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Technology Process of 3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

There total 3 articles about 3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 914362-04-2
3,4-dibromo-5-[(2-methoxyethoxy)methoxy]-5H-furan-2-one

: 938043-31-3
piperidin-1-yl-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-methanone

: 1395316-26-3
3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride; In tetrahydrofuran; water; at 120 ℃; under 12929 Torr; Inert atmosphere; Microwave irradiation; Autoclave;
DOI:10.1016/j.bmc.2012.06.032

Reference yield:

: 14047-29-1
4-carboxyphenylboronic acid

: 1395316-26-3
3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: ethyl acetate / 4 h / Inert atmosphere

2: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation; Autoclave

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; benzotriazol-1-ol; triethylamine; cesium fluoride; In tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1016/j.bmc.2012.06.032

Reference yield:

: 180516-87-4
4-carboxyphenylboronic acid pinacol ester

: 1395316-26-3
3-bromo-5-(2-methoxy-ethoxymethoxy)-4-[4-(piperidine-1-carbonyl)-phenyl]-5H-furan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; cesium fluoride / tetrahydrofuran; water / 120 °C / 12929 Torr / Inert atmosphere; Microwave irradiation; Autoclave

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrabutylammomium bromide; benzotriazol-1-ol; triethylamine; cesium fluoride; In tetrahydrofuran; water; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2012.06.032