(3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

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Chemical Name:(3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol
CAS No.:851889-72-0
Molecular Formula:C₃₀H₅₄O₅Si₂
Molecular Weight:550.927
Hs Code.:

Synonyms:(3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

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Chemical Property of (3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

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Technology Process of (3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

There total 9 articles about (3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 851889-70-8
(3E,5S,6S,7R,8R,9S)-6-hydroxy-8,10-[(R)-4-methoxybenzilidenedioxy]-5,7,9-trimethyldec-3-enoic acid methyl ester

: 851889-72-0
(3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-lutidine / CH₂Cl₂ / -78 - 0 °C

2.1: ozone; pyridine / methanol / -78 °C

2.2: dimethyl sulfide / methanol / -78 - 0 °C

3.1: diethyl ether / 48 h / 20 °C

With pyridine; 2,6-dimethylpyridine; ozone; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ja043168j

Reference yield:

: (E)-(5R,6R,7S)-8-(tert-Butyl-diphenyl-silanyloxy)-6-hydroxy-5,7-dimethyl-oct-3-enoic acid methyl ester

: 851889-72-0
(3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 4.8 g / HCl / methanol / 3 h

2.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / -78 - 20 °C

3.1: ozone; pyridine / methanol / -78 °C

3.2: 92 percent / dimethyl sulfide / methanol / -78 - 20 °C

4.1: 85 percent / TiCl₄ / CH₂Cl₂ / -78 - -30 °C

5.1: HF*pyridine / tetrahydrofuran / 1 h / 0 °C

6.1: 4.8 g / p-toluenesulfonic acid / dimethylformamide / 5 h / 20 °C

7.1: 2,6-lutidine / CH₂Cl₂ / -78 - 0 °C

8.1: ozone; pyridine / methanol / -78 °C

8.2: dimethyl sulfide / methanol / -78 - 0 °C

9.1: diethyl ether / 48 h / 20 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; titanium tetrachloride; toluene-4-sulfonic acid; pyridine hydrogenfluoride; ozone; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja043168j

Reference yield:

: 851889-71-9
(E)-(5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-oct-3-enoic acid methyl ester

: 851889-72-0
(3R,4S,5S,6S,7S)-7-[(2R,4R,5S)-2-(4-Methoxy-phenyl)-5-methyl-[1,3]dioxan-4-yl]-5-methyl-6-triethylsilanyloxy-3-trimethylsilanyl-oct-1-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: ozone; pyridine / methanol / -78 °C

1.2: dimethyl sulfide / methanol / -78 - 0 °C

2.1: diethyl ether / 48 h / 20 °C

With pyridine; ozone; In methanol; diethyl ether;
DOI:10.1021/ja043168j