(E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester

Base Information

• Chemical Name: (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester
• CAS No.: 203917-42-4
• Molecular Formula: C₁₃H₁₄N₂O₄
• Molecular Weight: 262.265
• Mol file: 203917-42-4.mol

Synonyms:(E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester

Chemical Property of (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester

There total 4 articles about (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(E)-3-(2-Formyl-phenylcarbamoyl)-acrylic acid ethyl ester (203917-29-7) → (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester (203917-42-4)

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 24h; Ambient temperature;

DOI:10.1039/a707857i

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester (203917-42-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 53 percent / sodium hydrogen carbonate / CH₂Cl₂ / 1 h / Ambient temperature

2: 73 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

3: 82 percent / hydroxylamine hydrochloride, pyridine / ethanol / 24 h / Ambient temperature

With pyridine; hydroxylamine hydrochloride; sodium hydrogencarbonate; pyridinium chlorochromate; In ethanol; dichloromethane;

DOI:10.1039/a707857i

Reference yield:

(E)-3-(2-Hydroxymethyl-phenylcarbamoyl)-acrylic acid ethyl ester (106898-75-3) → (E)-3-[2-(Hydroxyimino-methyl)-phenylcarbamoyl]-acrylic acid ethyl ester (203917-42-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / pyridinium chlorochromate / CH₂Cl₂ / 1.5 h

2: 82 percent / hydroxylamine hydrochloride, pyridine / ethanol / 24 h / Ambient temperature

With pyridine; hydroxylamine hydrochloride; pyridinium chlorochromate; In ethanol; dichloromethane;

DOI:10.1039/a707857i

upstream raw materials:

(E)-3-(2-Formyl-phenylcarbamoyl)-acrylic acid ethyl ester

2-Aminobenzyl alcohol

fumaric acid ethyl ester mono chloride

(E)-3-(2-Hydroxymethyl-phenylcarbamoyl)-acrylic acid ethyl ester