1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Base Information

Chemical Name:1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine
CAS No.:151385-95-4
Molecular Formula:C₂₆H₂₈N₂O₂
Molecular Weight:400.521
Hs Code.:

Synonyms:1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Suppliers and Price of 1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

There total 1 articles about 1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 40426-24-2
((3r,5r,7r)-adamantan-1-yl)methyl methanesulfonate

: 22316-50-3
1-phenyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine

: 151385-95-4
1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: 1-phenyl 1,2,4,5-tetrahydro 2,4-dioxo 3H-1,5-benzodiazepine; With sodium hydride; In N,N-dimethyl-formamide; at 130 ℃; for 0.75h;

((3r,5r,7r)-adamantan-1-yl)methyl methanesulfonate; In N,N-dimethyl-formamide; at 150 ℃; for 6h; Further stages.;
DOI:10.1021/jm990967h

Reference yield: 52.0%

: 151385-95-4
1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: 151620-72-3
1-N-(adamant-1-ylmethyl)-3-azido-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

Guidance literature:: 1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine; With potassium tert-butylate; In tetrahydrofuran; at -78 ℃; for 0.5h;

With 2,4,6-Triisopropylbenzenesulfonyl azide; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Further stages.;
DOI:10.1021/jm990967h

Reference yield:

: 151385-95-4
1-N-(adamant-1-ylmethyl)-2,4-dioxo-5-N-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine

: (+)-N-[1-(adamant-1-ylmethyl)-2,4-dioxo-5-phenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3-yl]-N'-(4-hydroxyphenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuOK / tetrahydrofuran / 0.5 h / -78 °C

1.2: 52 percent / 2,4,6-triisopropylbenzenesulfonyl azide / tetrahydrofuran / 0.08 h / -78 °C

2.1: H₂ / 5percent Pd/CaCO₃ / ethanol; ethyl acetate / 5 h / 760.05 Torr

2.2: (1R)-(-)-10-camphorsulfonic acid / ethyl acetate

2.3: CH₂Cl₂ / 1 h / 23 °C

With potassium tert-butylate; hydrogen; 5percent Pd/CaCO₃; In tetrahydrofuran; ethanol; ethyl acetate; 1.1: Metallation / 1.2: Azidation / 2.1: Reduction / 2.2: Racemate resolution / 2.3: Addition;
DOI:10.1021/jm990967h