3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

Base Information

Chemical Name:3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide
CAS No.:1114089-08-5
Molecular Formula:C₂₂H₂₄F₂N₂O₄
Molecular Weight:418.44
Hs Code.:

Synonyms:3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

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Chemical Property of 3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

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Technology Process of 3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

There total 3 articles about 3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₂₃F₂NO₅

: 1114089-08-5
3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

Guidance literature:: With ammonia; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1016/j.bmc.2017.04.033

Reference yield:

: 1114089-06-3
(R)-6-allyl-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one

: 1114089-08-5
3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: chromium(VI) oxide; sulfuric acid / water; acetone / 0 °C

2: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 48 h / 20 °C

With chromium(VI) oxide; sulfuric acid; ammonia; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2017.04.033

Reference yield:

: (R)-6-allyl-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one

: 1114089-08-5
3-((R)-3-((S)-1-(4-(difluoromethoxy)phenyl)ethyl)-2-oxo-6-phenyl-1,3-oxazinan-6-yl)propanamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: borane-THF / tetrahydrofuran / 0 °C

1.2: 20 °C

2.1: chromium(VI) oxide; sulfuric acid / water; acetone / 0 °C

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; ammonia; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 48 h / 20 °C

With chromium(VI) oxide; borane-THF; sulfuric acid; ammonia; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/j.bmc.2017.04.033