2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

Base Information

Chemical Name:2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine
CAS No.:848613-83-2
Molecular Formula:C₂₁H₂₀N₆O₅S
Molecular Weight:468.493
Hs Code.:

Synonyms:2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

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Chemical Property of 2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

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Technology Process of 2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

There total 7 articles about 2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-phenoxy-N-[6-thiazol-2-yl-9-(4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-yl]-acetamide

: 848613-83-2
2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

Guidance literature:: With pyridine; ammonium hydroxide; In acetonitrile; at 0 ℃; for 0.166667h;
DOI:10.1021/ja0425280

Reference yield:

: 848613-82-1
2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

: 848613-83-2
2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 0.42 h / 20 °C

2.1: 1-hydroxybenzotriazole; pyridine / acetonitrile / 0.08 h / 0 °C

2.2: pyridine / acetonitrile / 0 - 20 °C

3.1: 211 mg / aq. NH₃; pyridine / acetonitrile / 0.17 h / 0 °C

With pyridine; ammonium hydroxide; benzotriazol-1-ol; In acetonitrile;
DOI:10.1021/ja0425280

Reference yield:

: 6-Thiazol-2-yl-9-((2R,4S,5R)-4-trimethylsilanyloxy-5-trimethylsilanyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-2-ylamine

: 848613-83-2
2-N-phenoxyacetyl 2-amino-6-(2-thiazolyl)-9-(2-deoxy-β-D-ribofuranosyl)purine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxybenzotriazole; pyridine / acetonitrile / 0.08 h / 0 °C

1.2: pyridine / acetonitrile / 0 - 20 °C

2.1: 211 mg / aq. NH₃; pyridine / acetonitrile / 0.17 h / 0 °C

With pyridine; ammonium hydroxide; benzotriazol-1-ol; In acetonitrile;
DOI:10.1021/ja0425280