4-Tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde

Base Information

Chemical Name:4-Tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde
CAS No.:107430-94-4
Molecular Formula:C₂₃H₃₄O₂Si
Molecular Weight:370.607
Hs Code.:
DSSTox Substance ID:DTXSID101128329

Synonyms:SCHEMBL8766824;KIURNEMQFWJFJK-UHFFFAOYSA-N;DTXSID101128329;4-tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde;4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-3-tricyclo[3.3.1.13,7]dec-1-ylbenzaldehyde;107430-94-4

Suppliers and Price of 4-Tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:370.232806857
Heavy Atom Count:26
Complexity:506

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=C(C=C(C=C1)C=O)C23CC4CC(C2)CC(C4)C3

Technology Process of 4-Tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde

There total 5 articles about 4-Tert-butyldimethylsilyloxy-3-(1-adamantyl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557-91-5
1,1-Dibromoethane

: 104224-85-3
2-(1-adamantyl)-4-bromo-1-<(tert-butyldimethylsilyl)oxy>benzene

: 107430-94-4
3-(1-adamantyl)-4-<(tert-butyldimethylsilyl)oxy>benzenecarboxaldehyde

Guidance literature:: With magnesium; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 106-41-2
4-bromo-phenol

: 107430-94-4
3-(1-adamantyl)-4-<(tert-butyldimethylsilyl)oxy>benzenecarboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / conc. H₂SO₄ / CH₂Cl₂ / 8 h / Ambient temperature

2: 86 percent / Et₃N, 4-(N,N-dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -70 deg C, 45 min, 2.) THF, from -40 deg C to RT

With dmap; n-butyllithium; sulfuric acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00026a006

Reference yield:

: 768-95-6
1-adamanthanol

: 107430-94-4
3-(1-adamantyl)-4-<(tert-butyldimethylsilyl)oxy>benzenecarboxaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / conc. H₂SO₄ / CH₂Cl₂ / 8 h / Ambient temperature

2: 86 percent / Et₃N, 4-(N,N-dimethylamino)pyridine / dimethylformamide / 4 h / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -70 deg C, 45 min, 2.) THF, from -40 deg C to RT

With dmap; n-butyllithium; sulfuric acid; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00026a006